International Journal of Clinical Biology and Biochemistry

International Journal of Clinical Biology and Biochemistry


International Journal of Clinical Biology and Biochemistry
International Journal of Clinical Biology and Biochemistry
2019, Vol. 1, Issue 2
Significance of vitamin B12 level as a risk factor metabolic syndrome in Saudi population

Ashgan Mohammed K Al-Manzlawi, Khalid O Abulnaja, Mazin A Zamzami, Qari M

Background: Metabolic syndrome (MetS) is a group of collective disease including obesity associated with diabetic and orhypertension. Therefore, the aim of the work is for monitoring plasma vitamin B12in association with BMI in Saudi subjects as a predictive biomarker for MetS. It was also our intention to provide a feasible approach for the early diagnosis of MetS. Subjects and methods: This study was carried out on sixty subjects divided into four groups each 15 subjects: Group (I): Normal healthy subjects as control. Group (II): including patients diagnosed as type II diabetic Patients. Group (III): including hypertensive patients Group (IV): including patient’s diabetic with hypertensive. Anthropometric analysis including BMI. Fasting blood samples was collected from all subjects for assay of glucose, HA1C and vitamin B12. Results: Data obtained showed that, vitamin B12 level was significantly decreased in the diabetic group, hypertensive and the combined group (diabetic + hypertensive) (P < 0.005) compared to control group. While the diabetic group showed a non-significant (P ˃ 0.05) difference versus hypertensive group, respectively. Moreover, a non-significant decrease in Vitamin B12 level was occurred in the combined (diabetic + hypertensive) group (P > 0.05) compared to the diabetic group and hypertensive group. A negative correlation between HA1C and B12 was recorded (r = -0.62) and with BMI (r = - 0.59). It was concluded that, vitamin B12 is a promising biomarker for differentiation between Met S and other diseases for management and prevent complications.
Download  |  Pages : 22-26
How to cite this article:
Ashgan Mohammed K Al-Manzlawi, Khalid O Abulnaja, Mazin A Zamzami, Qari M. Significance of vitamin B12 level as a risk factor metabolic syndrome in Saudi population. International Journal of Clinical Biology and Biochemistry. 2019; 1(2): 22-26.