International Journal of Clinical Biology and Biochemistry

International Journal of Clinical Biology and Biochemistry

Online ISSN: 2664-6196
Print ISSN: 2664-6188

International Journal of Clinical Biology and Biochemistry
Online and Print Journal   |   Indexed Journal   |   Refereed Journal   |   Peer Reviewed Journal
International Journal of Clinical Biology and Biochemistry
2019, Vol. 1, Issue 2
Monogenic diabetes in children

Aklima Afroze

Monogenic forms of diabetes account for approximately 1–2% of diabetes in children and adolescents, and its incidence has increased in recent years due to greater awareness and wider availability of genetic testing. Monogenic diabetes is due to single gene defects that primarily affect beta cell function with more than 30 different genes reported. Children with antibody-negative, C-peptide-positive diabetes should be evaluated and genetically tested for monogenic diabetes. Accurate genetic diagnosis impacts treatment in the most common types of monogenic diabetes, including the use of sulfonylureas in place of insulin or other glucose-lowering agents or discontinuing pharmacologic treatment altogether.
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