Ashgan Mohammed K Al-Manzlawi, Khalid O Abulnaja, Mazin A Zamzami, Qari M
Background: Metabolic syndrome (MetS) is a group of collective disease including obesity associated with diabetic and orhypertension. Therefore, the aim of the work is for monitoring plasma vitamin B12in association with BMI in Saudi subjects as a predictive biomarker for MetS. It was also our intention to provide a feasible approach for the early diagnosis of MetS. Subjects and methods: This study was carried out on sixty subjects divided into four groups each 15 subjects: Group (I): Normal healthy subjects as control. Group (II): including patients diagnosed as type II diabetic Patients. Group (III): including hypertensive patients Group (IV): including patient’s diabetic with hypertensive. Anthropometric analysis including BMI. Fasting blood samples was collected from all subjects for assay of glucose, HA1C and vitamin B12. Results: Data obtained showed that, vitamin B12 level was significantly decreased in the diabetic group, hypertensive and the combined group (diabetic + hypertensive) (P < 0.005) compared to control group. While the diabetic group showed a non-significant (P Ëƒ 0.05) difference versus hypertensive group, respectively. Moreover, a non-significant decrease in Vitamin B12 level was occurred in the combined (diabetic + hypertensive) group (P > 0.05) compared to the diabetic group and hypertensive group. A negative correlation between HA1C and B12 was recorded (r = -0.62) and with BMI (r = - 0.59). It was concluded that, vitamin B12 is a promising biomarker for differentiation between Met S and other diseases for management and prevent complications.
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