Vol. 5, Issue 2, Part A (2023)

Background: The adipose tissue-derived serine protease inhibitor (vaspin) and biochemical parameters perform many biological activities throughout the human body. Thus, an increase in their level in plasma and blood is directly associated with an increased risk of developing Diabetic mellitus (T2DM). However, the potential association between vaspin and biochemical parameters in patients with Diabetic mellitus (T2DM) is still not well understood and studies in this area are limited. The present study aimed to assessment the relationship between vaspin and biochemical parameters and its association with Diabetic mellitus (T2DM) in the population of Kirkuk, Iraq.
Methods: The current cross-sectional study included a total of 90 participants (53 with Diabetic mellitus (T2DM) and 37 healthy without. Diabetic mellitus (T2DM) and all of them underwent several important routine health examinations. The patients' ages ranged from 18 to 37 years. The samples were collected for the measurement of vaspin and biochemical parameters by biochemical and clinical measurement methods specified in this study. The association between vaspin and biochemical parameters in Diabetic mellitus (T2DM) was evaluated by statistical analysis methods represented by SPSS version 24, and the associations for these variables were found by Pearson's correlation.
Results: The mean value of glucose and vaspin for participants with Diabetic mellitus (T2DM) was significantly higher (P=0.001) and (P=0.01) compared to the control group respectively. While the mean value of vitamin B12 with Diabetic mellitus (T2DM) was low significantly (P=0.01) compared to the control group. Regarding vaspin values and biochemical parameters in Diabetic mellitus (T2DM), found that vaspin was significant positively correlated with blood glucose levels in Diabetic mellitus (T2DM) patients and negatively correlated with vitamin B12. While there was no significant correlation between vaspin and serum creatinine, Troponin and CK-MB in Diabetic mellitus (T2DM) patients.
Conclusions: Elevated levels of blood glucose and vaspin were observed in patients with (T2DM), and it was found decrease levels Vit B12 in patients, that there is a correlation between vaspin and biochemical parameters of (T2DM). This study recommend testing and screening for vaspin and biochemical parameters on a larger scale as it has been shown to be associated with Diabetic mellitus (T2DM).