Vol. 6, Issue 1, Part A (2024)

Asthma is a well-known illness of the lower respiratory tract. It has many phenotypes including allergic and non-allergic asthma. The mechanism of non-allergic is still not entirely understood. The aim of the study is to investigate IL-4 response during non-allergic asthma. Blood from non-allergic asthma patients and aged matched healthy controls were collected complete blood count (CBC) was performed on each sample and the serum level of IgE and IL-4 were estimated by enzyme linked immunosorbent assay (ELISA). The results of the current study showed that the majority of the asthmatic patients were between 51-60 years old and with a dominancy of females in compare to the healthy control group. The serum level of total IgE was significantly (p=0.02) elevated in asthma patients in comparison to healthy controls (122.4±6.9 ul/ml and 91.9±11.1 ul/ml, respectively). The serum level of total IL-4 was non-significantly (p=0.818) elevated in asthma patients in comparison to healthy controls (35.4±6.5 ul/ml and 30.9±7.7 ul/ml respectively). A strong significant and positive correlation was found between IgE and IL-4 in asthma patients (R2 = 0.7, p=0.00) in compare to no correlation found between them in healthy controls (R2 = 0.34, p=0.24). Finally, the ROC curve showed that IL-4 did not give a good performance in the discrimination of the disease in non-allergic asthma. In conclusion, the study suggest that IL-4 have a slight contribution in the mechanism of non-allergic asthma.