Vol. 6, Issue 1, Part A (2024)

Background: Breast cancer (BC) happens when cells in the breast grow in an uncontrolled way and form a lump called a tumor (primary cancer). Sometimes, cancer cells spread to other parts of the body through the blood and lymphatic system. This is called secondary cancer. There are different types of breast cancer, but they are treated in similar ways. Breast cancer is not infectious and cannot be passed on to other people. The stage of breast cancer means how big it is and if it has spread, and the grade of breast cancer is how quickly the cancer may grow.

Objective: The aims of the study were to assess the clinical utility of serum Leptin, and visfatin, in women with breast cancer for diagnostic and prognostic purpose.

Methods: Forty clinically and histopathologically confirmed female patients of the age group of 30‑70 years served as cases and 40 normal healthy females in the same age group served as controls. The parameters were estimated by standard biochemical methods.

Results: The highest percentage of age for women with BC equal to (32.58%) in the age group (56-65) years, with mean age, was 51.19 years and the statistical tests data obtained showed: highest significant elevation of leptin, visfatin, level in women with BC were 40.35±7.11 ng/ml, 51.26±9.05 ng/ml, as compared to control group 31.14±5.07 ng/ml, 21.60±4.62 ng/ml, respectively at (p<0.001).

Conclusion: The study showed that breast cancer patients had significantly higher levels of Leptin, Visfatin.