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International Journal of Clinical Biology and Biochemistry

Vol. 6, Issue 1, Part B (2024)

Exploring 8-hydroxy-2-deoxyguanosine as a biomarker of oxidative DNA damage in various diseases and pathological conditions: Review

Author(s):

Sherzad Haji Jumaah and Dr. Ardawan Fathi Ali

Abstract:

Background: 8-Hydroxy-2-deoxyguanosine is a biomarker of oxidative stress, released from damaged DNA due to disease processes and chemical exposure. Several studies targeted the levels of this biomarker to evaluate the detrimental effects on the level of genetic material.
Materials and Methods: Keywords, such as: 8-Hydroxy-2-deoxyguanosine, 8-OHdG,oxidative stress, were searched in many search engines to review 8-Hydroxy-2-deoxyguanosine levels in most of the available studies in order to clarify the degree of DNA damage in various pathological conditions by determining the level of the above mentioned biomarker. 
Results: in most of the reviewed studies, such as: neurodegenerative disorders, malignant conditions, diabetes mellitus, among other inflammatory processes, the concentrations of 8-Hydroxy-2-deoxyguanosine were higher than in control groups. Surprisingly, the few studies conducted on alcoholics showed a decline in the levels of this biomarker compared to non-alcohol drinkers.
Conclusion: 8-Hydroxy-2-deoxyguanosine is one of the vital DNA damage indicators which needs to be given more attention in terms of seeking the harmful oxidative burden on human genetic material for providing more robust measures to early detection such harms before progressing to severe and irreversible health problems.

Pages: 126-139  |  93 Views  25 Downloads


International Journal of Clinical Biology and Biochemistry
How to cite this article:
Sherzad Haji Jumaah and Dr. Ardawan Fathi Ali. Exploring 8-hydroxy-2-deoxyguanosine as a biomarker of oxidative DNA damage in various diseases and pathological conditions: Review. Int. J. Clin. Biol. Biochem. 2024;6(1):126-139. DOI: 10.33545/26646188.2024.v6.i1b.66
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