Vol. 7, Issue 1, Part A (2025)

Introduction: Obesity is considered as an important public health problem by the World Health Organization. Obesity is associated with increased rates of dyslipidemis (DLP) and other cardiovascular risk factors. Obese adolescents with elevated lipid concentrations show higher rates of DLP in later life.
Objective: The main objective of this study was to find out the association of serum iron status and lipid profile in obese adolescents.
Methods: This cross-sectional analytical study was conducted in the Department of Biochemistry, Sir Salimullah Medical College, Dhaka during the period of July, 2019 to June 2020. In this study, a total 90 adolescents subjects were selected according to inclusion and exclusion criteria. Total participants were divided into three groups according to BMI categories-each group comprised of 30 subjects. 
Results: In this study, a total 90 subjects were selected according to inclusion and exclusion criteria. Each group comprised of 30 subjects. Normal weight, overweight and obese adolescents were considered as Group-I (control), Group-II and Group-III respectively. Mean values of TC, TG and LDL-C were significantly higher (p<0.001) and mean value of HDL-C was significantly lower (p<0.001) in obese subjects in comparison to overweight and normal weight of adolescents. It was evident from the study that, a significant linear relationship between iron status with lipid profile and BMI categories of adolescents. These findings suggest that iron deficiency is more common in overweight or obese subjects than healthy-weight subjects. These findings were in line with the observation that obesity is an inflammatory state that increases acute-phase reactants and ferritin acts as an acute-phase protein therefore, its level in plasma increased in response to obesity-related inflammation. 
Conclusion: Furthermore, low serum iron and TIBC and high serum ferritin were observed in obese group than group I and group II. Meanwhile, our results also indicated that adolescents with dyslipidemia had lower serum iron than adolescents without dyslipidemia. Increased Frequency of dyslipidemia is evident with the progressive increase of BMI among the adolescents. Dyslipidemic adolescents have lower serum iron and TIBC and higher serum ferritin.